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The heartburn medication Prilosec (Omeprazole), which is one of nine proton pump inhibitor (PPI) medications, has been linked to bone fractures, heart attacks, cardiac birth defects and severe kidney disease, including Prilosec kidney failure and Prilosec renal failure. Long-term use of Prilosec has been associated with a tripled risk of kidney inflammation, or nephritis. This over-the-counter antacid medication is commonly used to treat heartburn and gastroesophageal reflux disease (GERD), ulcers in the stomach and small intestine, and inflammation of the esophagus.
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